unexplained infertility

26 Oct, 2022

Unexplained Infertility


The unexplained infertility is when fertility testing hasn't found a cause to explain a person or couples’ infertility and therefore, ranges from the not so easily diagnosed to the not so well understood. In a layman’s language Unexplained infertility is a term healthcare providers use to describe infertility after tests reveal no obvious cause for your fertility problems.

unexplained infertility

molecular defects

Though significant advances have occurred in the diagnosis and treatment of reproductive disorders, people can still have trouble in conceiving without any known reasons. The couples diagnosed to have unexplained infertility by definition have no underlying reason for infertility. This is thus a heterogenous group with undiagnosed but varied subtle or molecular defects.

Studies from multiple hospitals have suggested that about 10% of the couples face this issue, and up to 30% of couples who are in treatment for infertility end up being diagnosed with it. There is no standard prescribed list of investigations for evaluation. Most clinicians rely on their own experience as well as availability and cost of tests to guide them. Fellowship in Reproductive Medicine helps gynecologists understand the complexities of unexplained infertility.

When do we know it is a case of UI?

Specialists only diagnose unexplained infertility after both have completed fertility evaluations. These tests often reveal:

  • • No uterine abnormalities or structural issues with your uterus
  • • Ovulation occurs at regular intervals
  • • Your fallopian tubes are open, with no obstructions
  • • Your egg count is good
  • • Your brain produces normal levels of the hormones needed for reproduction
  • • Your partner’s semen analysis is normal

Is it possible to get pregnant with unexplained infertility?

Yes, it is possible to conceive with unexplained infertility.

Did you know???

Study from National Institute of Health (NIH) found that 92% of couples with unexplained infertility who had fertility treatments ultimately had a child.

fertility treatments ultimately

What are the causes of unexplained infertility?

Unexplained infertility is most likely caused by the presence of multiple factors that don't on their own lead to infertility but decrease the chances of conception when in combination. Here are some possible reasons for unexplained infertility:

Women dealing with infertility usually have an underlying condition that causes their fertility issues, like Polycystic Ovary Syndrome (PCOS) or Endometriosis.

fertility treatments ultimately

assisted reproductive technology

Assisted Reproductive Technology



lifestyle change

Lifestyle change

But there’s a hope that’s waiting for you in the dark…

Having unexplained infertility does not mean there's a 0% chance of conceiving, but it does mean that your chances of getting pregnant without medical assistance are lower per cycle. Many patients with unexplained infertility conceive while awaiting treatment.

To know more about unexplained infertility in detail, enroll for the Advanced Reproductive Medicine Courses and the Basic Infertility Course by Medline Academics.

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